Epigenetic regulation in diabetic vascular complications
نویسندگان
چکیده
منابع مشابه
Regulation of RAGE for Attenuating Progression of Diabetic Vascular Complications
Diabetic angiopathy including micro- and macroangiopathy is concerned with high rate of morbidity and mortality in patients with long-standing diabetes. Receptor for advanced glycation end products (RAGE) and its ligands have been considered as important pathogenic triggers for the progression of the vascular injuries in diabetes. The deleterious link between RAGE and diabetic angiopathy has be...
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The cardiovascular complications associated with diabetes and the closely related metabolic syndrome are of increasing clinical importance throughout the world and especially in the Western hemisphere.1 Although insulin resistance and hyperglycemia are thought to play a pathogenic role during the progression of atherosclerosis, the precise mechanisms involved are not completely clear.2 One fact...
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Diabetic complications are the major causes of morbidity and mortality in patients with diabetes. Microvascular complications include retinopathy, nephropathy and neuropathy, which are leading causes of blindness, end-stage renal disease and various painful neuropathies; whereas macrovascular complications involve atherosclerosis related diseases, such as coronary artery disease, peripheral vas...
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The vascular complications of diabetes significantly impact the quality of life and mortality in diabetic patients. Extensive evidence from various human clinical trials has clearly established that a period of poor glycemic control early in the disease process carries negative consequences, such as an increase in the development and progression of vascular complications that becomes evident ma...
متن کاملPrevention for Micro- and Macro-Vascular Complications in Diabetic Patients
One of the goals in long-term cares for patients with diabetes mellitus (DM) is to prevent the development of micro-and macrovascular complications (The International Diabetes Federation, 2011). To achieve this purpose, an adequate control of blood pressure (BP) as well as a good glycaemic control is crucial (The International Diabetes Federation, 2011). The American Diabetes Association recomm...
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ژورنال
عنوان ژورنال: Journal of Molecular Endocrinology
سال: 2019
ISSN: 0952-5041,1479-6813
DOI: 10.1530/jme-19-0170